81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) hinein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion in this field that Aß may Beryllium produced from its precursor rein a physiologically gewöhnlich pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
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Very recently he also investigated the role of microglia and inflammation rein neurodegenerative disorders. This work Lumineszenzdiode to the spectacular finding that microglial phagocytosis may Beryllium impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted hinein the identification of TREM2 as a CSF marker for microglial activity. In a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
If you have already acquired a copyright rein a different country, ur team will help you with transferring it and will advise you on your way to obtaining a German driving permit.
Is it possible for a good driving student to register for the test after having lessons only rein special driving situations? No, that is not possible because of the legal regulations.
We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to in vivo models and life imaging.
Ur learning-type check helps you to learn how to learn more efficiently. Success may Beryllium improved hinein a short time.
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We will give you driving lessons designed to suit your own particular needs not only during the week but also on Saturdays. Rein this way you Weitere Informationen erhalten will get your driving licence as quickly as possible.
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